AI-redesigned antibody fragments show a route to targeting proteins inside cells
University of Essex researchers and international collaborators report using AI-guided protein redesign to convert 672 antibodies into stable intracellular antibody fragments, known as intrabodies. The work, published in Nature Communications, identifies electrical charge as a key determinant of whether such fragments remain functional inside human cells. The molecules are to be made freely available for research on proteins linked to Alzheimer’s, Parkinson’s, Huntington’s disease and motor neurone disease.